dfpk: Bayesian Dose-Finding Designs using Pharmacokinetics (PK) for Phase I Clinical Trials

Statistical methods involving PK measures are provided, in the dose allocation process during a Phase I clinical trials. These methods, proposed by Ursino et al, (2017) <doi:10.1002/bimj.201600084>, enter pharmacokinetics (PK) in the dose finding designs in different ways, including covariates models, dependent variable or hierarchical models. This package provides functions to generate data from several scenarios and functions to run simulations which their objective is to determine the maximum tolerated dose (MTD).

Version: 3.5.1
Depends: R (≥ 3.4.0), Rcpp (≥ 0.12.11), rstan (≥ 2.18.1)
Imports: ggplot2 (≥ 2.0.0), dfcrm, methods, stats, graphics, grDevices, PK
LinkingTo: StanHeaders (≥ 2.18.0), rstan (≥ 2.18.1), BH (≥ 1.66), Rcpp (≥ 0.12.0), RcppEigen
Published: 2018-11-09
Author: Artemis Toumazi [cre, aut], Sarah Zohar [aut], Moreno Ursino [aut], Trustees of Columbia University [cph] (R/stanmodels.R), French National Institute of Health and Medical Research [cph]
Maintainer: Artemis Toumazi <artemis.toumazi at gmail.com>
BugReports: http://github.com/artemis-toumazi/dfpk/issues
License: GPL (≥ 3) | file LICENSE
Copyright: stanmodels.R is copyright 2015, 2016, 2017 Trustees of Columbia University. All other files are copyright French National Institute of Health and Medical Research.
URL: http://github.com/artemis-toumazi/dfpk
NeedsCompilation: yes
SystemRequirements: GNU make
Materials: README
In views: Bayesian, ClinicalTrials, ExperimentalDesign, Pharmacokinetics
CRAN checks: dfpk results


Reference manual: dfpk.pdf


Package source: dfpk_3.5.1.tar.gz
Windows binaries: r-devel: dfpk_3.5.1.zip, r-release: dfpk_3.5.1.zip, r-oldrel: dfpk_3.5.1.zip
macOS binaries: r-release (arm64): dfpk_3.5.1.tgz, r-oldrel (arm64): dfpk_3.5.1.tgz, r-release (x86_64): dfpk_3.5.1.tgz, r-oldrel (x86_64): dfpk_3.5.1.tgz
Old sources: dfpk archive


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